Febuxostat Attenuates Renal Damage besides Exerting Hypouricemic Effect in Streptozotocin-Induced Diabetic Rats

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Febuxostat Attenuates Renal Damage besides Exerting Hypouricemic Effect in Streptozotocin-Induced Diabetic Rats

Aim. In this study, we aimed to investigate the effects of febuxostat, a novel inhibitor of xanthine oxidase (XO), on renal damage in streptozotocin- (STZ-) induced diabetic rats. Methods. Diabetes was induced by the intraperitoneal injection of STZ in male Sprague-Dawley rats. Sham-injected rats served as controls. The control and diabetic rats were treated with and without febuxostat for 8 we...

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Protective Effect of Royal Jelly against Renal Damage in Streptozotocin Induced Diabetic Rats

Background: Royal jelly has been shown to have antioxidant and antidiabetic effects. The objective of this study was to evaluate the protective effect of RJ against kidney damage in streptozotocin induced diabetic rats. Methods: Thirty two male Wistar rats were divided randomly into four groups (n=8 per group). Normal control and diabetic control groups received 1cc/day distilled water, norm...

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Low Protein Diet Inhibits Uric Acid Synthesis and Attenuates Renal Damage in Streptozotocin-Induced Diabetic Rats

AIM Several studies indicated that hyperuricemia may link to the worsening of diabetic nephropathy (DN). Meanwhile, low protein diet (LPD) retards exacerbation of renal damage in chronic kidney disease. We then assessed whether LPD influences uric acid metabolism and benefits the progression of DN in streptozotocin- (STZ-) induced diabetic rats. METHODS STZ-induced and control rats were both ...

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protective effect of royal jelly against renal damage in streptozotocin induced diabetic rats

background: royal jelly has been shown to have antioxidant and antidiabetic effects. the objective of this study was to evaluate the protective effect of rj against kidney damage in streptozotocin induced diabetic rats. methods: thirty two male wistar rats were divided randomly into four groups (n=8 per group). normal control and diabetic control groups received 1cc/day distilled water, normal ...

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Protective Effect of Royal Jelly against Renal Damage in Streptozotocin Induced Diabetic Rats

Background: Royal jelly has been shown to have antioxidant and antidiabetic effects. The objective of this study was to evaluate the protective effect of RJ against kidney damage in streptozotocin induced diabetic rats. Methods: Thirty two male Wistar rats were divided randomly into four groups (n=8 per group). Normal control and diabetic control groups received 1cc/day distilled water, normal ...

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ژورنال

عنوان ژورنال: International Journal of Nephrology

سال: 2017

ISSN: 2090-214X,2090-2158

DOI: 10.1155/2017/2739539